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====== Neuroblastoma Data Integration Challenge ====== | ====== Neuroblastoma Data Integration Challenge ====== | ||
Examine the power of data integration in a real-world clinical setting. Neuroblastoma is the most common extracranial solid tumor in children. The base study compared RNA-seq and Agilent microarray gene expression profiles for clinical endpoint prediction of 498 children patients (FDA SEQC - [[https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0694-1|Zhang et al, Genome Biology 2015]]). The published summary data are complemented by raw signal level data for gene expression arrays, RNA-Seq expression profiles, and extended clinical meta-data (event-free & overall survival times, multiple prognostic markers, therapy data). For this challenge, we **newly provide matched aCGH data** for 145 of these patients for CNV/CNA analysis (Fischer lab, Köln - | Examine the power of data integration in a real-world clinical setting. Neuroblastoma is the most common extracranial solid tumor in children. The base study compared RNA-seq and Agilent microarray gene expression profiles for clinical endpoint prediction of 498 children patients (FDA SEQC - [[https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0694-1|Zhang et al, Genome Biology 2015]]). The published summary data are complemented by raw signal level data for gene expression arrays, RNA-Seq expression profiles, and extended clinical meta-data (event-free & overall survival times, multiple prognostic markers, therapy data). For this challenge, we **newly provide matched aCGH data** for 145 of these patients for CNV/CNA analysis (Fischer lab, Köln - | ||
- | [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459278/|Stigliani et al, Neoplasia 2012]] | + | [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459278/|Stigliani et al, Neoplasia 2012]], |
[[http://onlinelibrary.wiley.com/doi/10.1002/ijc.27432/full|Coco at el, IJC 2012]], [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668636/|Kocak et al, Cell Death Dis 2013]], | [[http://onlinelibrary.wiley.com/doi/10.1002/ijc.27432/full|Coco at el, IJC 2012]], [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668636/|Kocak et al, Cell Death Dis 2013]], | ||
[[http://onlinelibrary.wiley.com/doi/10.1002/gcc.22174/full|Theissen et al, Genes Chromosomes Cancer 2014]]). | [[http://onlinelibrary.wiley.com/doi/10.1002/gcc.22174/full|Theissen et al, Genes Chromosomes Cancer 2014]]). |
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